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Possible link between D-lactic acid and schizophrenia: some commonality in symptoms

The following proposes that high levels of lactic acid, produced by bacteria fermentation may be involved in causing schizophrenia.

Multiple cross correlations between high lactate levels and schizophrenia are listed. It is further proposed the lactic acid may be transported to the central nervous system via a damaged olfactory system. 


Studies have found an overpopulation of L. Gasseri in schizophrenia, L. Gasseri is an L and D lactic acid producing bacteria. The over population is probably caused by a virus (phage) which alters the DNA of the bacteria. 


Elevated lactate has been measured  in brain of schizophrenia patients.

Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study 


A study has measured increased acidity in the brains of schizophrenics


Elevated D lactate has also been measured in the blood;

Quantitative Analyses of Schizophrenia-Associated Metabolites in Serum: Serum D-Lactate Levels Are Negatively Correlated with Gamma-Glutamylcysteine in Medicated Schizophrenia Patients 


general information on D-Lactic acidosis


Wider blood vessels have been observed in schizophrenia patients, Dunedin study


Microvascular Abnormality in Schizophrenia as Shown by Retinal Imaging


D-lactic acid has been shown to change small blood vessel, in cows


Schizophrenia is linked with alterations in the small vessels in the blood brain barrier


lactic acid has an effect on cd4+ increasing inflammation, causing over trimming of connections in the brain

(article discussing how inflammation and over trimming is being targeted with MS drugs)


Lactate effect on immune cells 


“patients had a significantly greater percentage of CD8+ and CD4+ CD45RA+ cells before stimulation and significantly higher fluorescence intensity of CD45RA on CD4+ and CD8+ cells before and after stimulation. “


markers increased by D lactic acid dosing In human, parenteral infusion of D-L-lactate causes increases in pyruvate, alanine, 3-hydroxybutyrate, and acetoacetate

Study showing an increase of some of the same markers in schizophrenia patients


cows injected with D and L lactic acid, D lactic had most effect as neurotoxin, it also showed (Figure 3) D-lactic acid had a large effect on pH, Post mortem on the brains of Schizophrenia patients have been found to have lower pH.  

(if the study does not display, use a different web browser)


lactic acid may be able to travel from the oral cavity to the brain. There is an association between early life influenzae (and other pathogens) infections and Schizophrenia, influenzae virus (and other pathogens) uses olfactory nerve as pathway to CNS

Here is PANDAS study noting antibodies travelled along olfactory nerve to the brain, and GAS infection caused holes in the BBB


Capillaries in the olfactory bulb but not the cortex are highly susceptible to virus-induced vascular leak and promote viral neuroinvasion.


study showing Schizophrenia patients have altered olfactory function

Reduced volume


Schizophrenia is linked with altered breathing

Its has been shown that lactate in the olfactory bulb alters breathing

D-lactic acid in sinus secretions has been measured


Study mentions D-lactic acid may have effect on bone formation , search word bone , osteomalacia  normally shows up in the mouth first


Study schizophrenia patients have altered mouth structure , wider palate , Abnormalities Of The Mouth Associated With Schizophrenia



A study has shown how bad D-lactate is for brain, D-Lactate altered mitochondrial energy production in rat brain and heart but not liver, schizophrenia is also associated with cardiac problems


Increased lactate level can also have a detrimental effect via the gut with increase reactive oxygen species

The excess lactic acid generated chemicals called reactive oxygen species that can damage cells and have links to aging-related changes in organs and tissues.

(Igor Iatsenko     Bruno Lemaitre


Implications for reactive oxygen species in schizophrenia pathogenesis.


Removal of carbs, which is the substrate used by lactic acid bacteria, shows improvement in schizophrenia.

 Low carb diet clears symptoms, case report

Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature


Low-Carbohydrate Diet Superior to Antipsychotic Medications


30day Fast in USSR 64% success rate.


The supplement used for the removal of lactic acid cause improvement in schizophrenia patients.


NAC (N-Acetyl Cysteine) used for D-lactic acid (search NAC)


Study showing SCH patients are 20 times more likely to have UTI


Study showing Ph of urine affects number of UTIs you get. More acidic urie results in more UTIs



Sauna bathing has been shown to reduce the risk of Psychotic Disorders

Saunas are known as a way of shedding excess protons, as sweat is slightly acidic. Saunas also increase the mean base excess by 20.3%

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