Possible link between D-lactic acid and schizophrenia: some commonality in symptoms

The following proposes that high levels of lactic acid, produced by bacteria fermentation may be involved in causing schizophrenia.

Multiple cross correlations between high lactate levels and schizophrenia are listed. It is further proposed the lactic acid may be transported to the central nervous system via a damaged olfactory system. 


 

Studies have found an overpopulation of L. Gasseri in schizophrenia, L. Gasseri is an L and D lactic acid producing bacteria. The over population is probably caused by a virus (phage) which alters the DNA of the bacteria.

https://www.washingtonpost.com/news/to-your-health/wp/2015/08/31/unusual-pattern-of-oral-bacteria-linked-to-schizophrenia-say-two-new-studies/ 

 

Elevated lactate has been measured  in brain of schizophrenia patients.

Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study

 

https://www.ncbi.nlm.nih.gov/pubmed/27898072 

 

A study has measured increased acidity in the brains of schizophrenics 

 https://www.scientificamerican.com/article/are-some-psychiatric-disorders-a-ph-problem/


 

Elevated D lactate has also been measured in the blood;

Quantitative Analyses of Schizophrenia-Associated Metabolites in Serum: Serum D-Lactate Levels Are Negatively Correlated with Gamma-Glutamylcysteine in Medicated Schizophrenia Patients

https://www.ncbi.nlm.nih.gov/pubmed/25004141 


 

general information on D-Lactic acidosis https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-September-15.pdf

 

Wider blood vessels have been observed in schizophrenia patients, Dunedin study

 

Microvascular Abnormality in Schizophrenia as Shown by Retinal Imaging

https://www.ncbi.nlm.nih.gov/pubmed/24030514


 

D-lactic acid has been shown to change small blood vessel, in cows

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559443/




 

Schizophrenia is linked with alterations in the small vessels in the blood brain barrier

https://www.sciencedaily.com/releases/2017/10/171010105629.htm

 

lactic acid has an effect on cd4+ increasing inflammation, causing over trimming of connections in the brain

(article discussing how inflammation and over trimming is being targeted with MS drugs)

https://www.theguardian.com/society/2017/nov/03/radical-new-approach-to-schizophrenia-treatment-begins-trial

 

Lactate effect on immune cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504715/ 

 

“patients had a significantly greater percentage of CD8+ and CD4+ CD45RA+ cells before stimulation and significantly higher fluorescence intensity of CD45RA on CD4+ and CD8+ cells before and after stimulation. “

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1930154/

 

markers increased by D lactic acid dosing In human, parenteral infusion of D-L-lactate causes increases in pyruvate, alanine, 3-hydroxybutyrate, and acetoacetate

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894545/

Study showing an increase of some of the same markers in schizophrenia patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526727/

 

cows injected with D and L lactic acid, D lactic had most effect as neurotoxin, it also showed (Figure 3) D-lactic acid had a large effect on pH, Post mortem on the brains of Schizophrenia patients have been found to have lower pH.  

(if the study does not display, use a different web browser) 

https://www.physiology.org/doi/full/10.1152/ajpendo.00063.2007

 

https://www.physiology.org/doi/prev/20171106-aop/abs/10.1152/ajpendo.00063.2007

 

https://www.nature.com/articles/npp2017167





 

lactic acid may be able to travel from the oral cavity to the brain. There is an association between early life influenzae (and other pathogens) infections and Schizophrenia, influenzae virus (and other pathogens) uses olfactory nerve as pathway to CNS

Here is PANDAS study noting antibodies travelled along olfactory nerve to the brain, and GAS infection caused holes in the BBB 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701547/

 

Capillaries in the olfactory bulb but not the cortex are highly susceptible to virus-induced vascular leak and promote viral neuroinvasion.

https://www.ncbi.nlm.nih.gov/pubmed/25956408

 

study showing Schizophrenia patients have altered olfactory function

https://www.nature.com/articles/1395343

Reduced volume

https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.157.5.828

 

Schizophrenia is linked with altered breathing 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306403/

Its has been shown that lactate in the olfactory bulb alters breathing 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765808/

D-lactic acid in sinus secretions has been measured

https://journals.sagepub.com/doi/abs/10.2500/105065890782009370?journalCode=ajrb

 

Study mentions D-lactic acid may have effect on bone formation , search word bone , osteomalacia  normally shows up in the mouth first

https://academic.oup.com/jn/article/135/7/1619/4663874

 

Study schizophrenia patients have altered mouth structure , wider palate , Abnormalities Of The Mouth Associated With Schizophrenia

 

https://www.sciencedaily.com/releases/2007/03/070314082032.htm

 


 

A study has shown how bad D-lactate is for brain, D-Lactate altered mitochondrial energy production in rat brain and heart but not liver, schizophrenia is also associated with cardiac problems 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292964/

 

Increased lactate level can also have a detrimental effect via the gut with increase reactive oxygen species

The excess lactic acid generated chemicals called reactive oxygen species that can damage cells and have links to aging-related changes in organs and tissues.

https://www.medicalnewstoday.com/articles/323705.php

(Igor Iatsenko  igor.iatsenko@epfl.ch     Bruno Lemaitre    bruno.lemaitre@epfl.ch)

 

Implications for reactive oxygen species in schizophrenia pathogenesis.

https://www.ncbi.nlm.nih.gov/pubmed/26589391



 

Removal of carbs, which is the substrate used by lactic acid bacteria, shows improvement in schizophrenia.

 Low carb diet clears symptoms, case report

Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

 

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-6-10


 

Low-Carbohydrate Diet Superior to Antipsychotic Medications

 

https://www.psychologytoday.com/au/blog/diagnosis-diet/201709/low-carbohydrate-diet-superior-antipsychotic-medications


 

30day Fast in USSR 64% success rate. http://orthomolecular.org/library/jom/1971/pdf/1971-v03n01-p002.pdf

 

The supplement used for the removal of lactic acid cause improvement in schizophrenia patients.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815074/

 

NAC (N-Acetyl Cysteine) used for D-lactic acid (search NAC)

 

https://cfsremission.com/2015/09/22/approaches-to-d-lactic-acidosis/.



 

Study showing SCH patients are 20 times more likely to have UTI

https://www.ncbi.nlm.nih.gov/pubmed/24499998

 

Study showing Ph of urine affects number of UTIs you get. More acidic urie results in more UTIs

https://www.sciencedaily.com/releases/2015/06/150625161623.htm


 

 

Sauna bathing has been shown to reduce the risk of Psychotic Disorders

https://www.karger.com/Article/Fulltext/493392

Saunas are known as a way of shedding excess protons, as sweat is slightly acidic. Saunas also increase the mean base excess by 20.3% 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941775/

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