CRANLEYTECH
Possible link between D-lactic acid and schizophrenia: some commonality in symptoms
The following proposes that high levels of lactic acid, produced by bacteria fermentation may be involved in causing schizophrenia.
Multiple cross correlations between high lactate levels and schizophrenia are listed. It is further proposed the lactic acid may be transported to the central nervous system via a damaged olfactory system.
Studies have found an overpopulation of L. Gasseri in schizophrenia, L. Gasseri is an L and D lactic acid producing bacteria. The over population is probably caused by a virus (phage) which alters the DNA of the bacteria.
Elevated lactate has been measured in brain of schizophrenia patients.
Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study
https://www.ncbi.nlm.nih.gov/pubmed/27898072
A study has measured increased acidity in the brains of schizophrenics
https://www.scientificamerican.com/article/are-some-psychiatric-disorders-a-ph-problem/
Elevated D lactate has also been measured in the blood;
Quantitative Analyses of Schizophrenia-Associated Metabolites in Serum: Serum D-Lactate Levels Are Negatively Correlated with Gamma-Glutamylcysteine in Medicated Schizophrenia Patients
https://www.ncbi.nlm.nih.gov/pubmed/25004141
general information on D-Lactic acidosis https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-September-15.pdf
Wider blood vessels have been observed in schizophrenia patients, Dunedin study
Microvascular Abnormality in Schizophrenia as Shown by Retinal Imaging
https://www.ncbi.nlm.nih.gov/pubmed/24030514
D-lactic acid has been shown to change small blood vessel, in cows
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559443/
Schizophrenia is linked with alterations in the small vessels in the blood brain barrier
https://www.sciencedaily.com/releases/2017/10/171010105629.htm
lactic acid has an effect on cd4+ increasing inflammation, causing over trimming of connections in the brain
(article discussing how inflammation and over trimming is being targeted with MS drugs)
Lactate effect on immune cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504715/
“patients had a significantly greater percentage of CD8+ and CD4+ CD45RA+ cells before stimulation and significantly higher fluorescence intensity of CD45RA on CD4+ and CD8+ cells before and after stimulation. “
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1930154/
markers increased by D lactic acid dosing In human, parenteral infusion of D-L-lactate causes increases in pyruvate, alanine, 3-hydroxybutyrate, and acetoacetate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894545/
Study showing an increase of some of the same markers in schizophrenia patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526727/
cows injected with D and L lactic acid, D lactic had most effect as neurotoxin, it also showed (Figure 3) D-lactic acid had a large effect on pH, Post mortem on the brains of Schizophrenia patients have been found to have lower pH.
(if the study does not display, use a different web browser)
https://www.physiology.org/doi/full/10.1152/ajpendo.00063.2007
https://www.physiology.org/doi/prev/20171106-aop/abs/10.1152/ajpendo.00063.2007
https://www.nature.com/articles/npp2017167
lactic acid may be able to travel from the oral cavity to the brain. There is an association between early life influenzae (and other pathogens) infections and Schizophrenia, influenzae virus (and other pathogens) uses olfactory nerve as pathway to CNS
Here is PANDAS study noting antibodies travelled along olfactory nerve to the brain, and GAS infection caused holes in the BBB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701547/
Capillaries in the olfactory bulb but not the cortex are highly susceptible to virus-induced vascular leak and promote viral neuroinvasion.
https://www.ncbi.nlm.nih.gov/pubmed/25956408
study showing Schizophrenia patients have altered olfactory function
https://www.nature.com/articles/1395343
Reduced volume
https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.157.5.828
Schizophrenia is linked with altered breathing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306403/
Its has been shown that lactate in the olfactory bulb alters breathing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765808/
D-lactic acid in sinus secretions has been measured
https://journals.sagepub.com/doi/abs/10.2500/105065890782009370?journalCode=ajrb
Study mentions D-lactic acid may have effect on bone formation , search word bone , osteomalacia normally shows up in the mouth first
https://academic.oup.com/jn/article/135/7/1619/4663874
Study schizophrenia patients have altered mouth structure , wider palate , Abnormalities Of The Mouth Associated With Schizophrenia
https://www.sciencedaily.com/releases/2007/03/070314082032.htm
A study has shown how bad D-lactate is for brain, D-Lactate altered mitochondrial energy production in rat brain and heart but not liver, schizophrenia is also associated with cardiac problems
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292964/
Increased lactate level can also have a detrimental effect via the gut with increase reactive oxygen species
The excess lactic acid generated chemicals called reactive oxygen species that can damage cells and have links to aging-related changes in organs and tissues.
https://www.medicalnewstoday.com/articles/323705.php
(Igor Iatsenko igor.iatsenko@epfl.ch Bruno Lemaitre bruno.lemaitre@epfl.ch)
Implications for reactive oxygen species in schizophrenia pathogenesis.
https://www.ncbi.nlm.nih.gov/pubmed/26589391
Removal of carbs, which is the substrate used by lactic acid bacteria, shows improvement in schizophrenia.
Low carb diet clears symptoms, case report
Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-6-10
Low-Carbohydrate Diet Superior to Antipsychotic Medications
30day Fast in USSR 64% success rate. http://orthomolecular.org/library/jom/1971/pdf/1971-v03n01-p002.pdf
The supplement used for the removal of lactic acid cause improvement in schizophrenia patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815074/
NAC (N-Acetyl Cysteine) used for D-lactic acid (search NAC)
https://cfsremission.com/2015/09/22/approaches-to-d-lactic-acidosis/.
Study showing SCH patients are 20 times more likely to have UTI
https://www.ncbi.nlm.nih.gov/pubmed/24499998
Study showing Ph of urine affects number of UTIs you get. More acidic urie results in more UTIs
https://www.sciencedaily.com/releases/2015/06/150625161623.htm
Sauna bathing has been shown to reduce the risk of Psychotic Disorders
https://www.karger.com/Article/Fulltext/493392
Saunas are known as a way of shedding excess protons, as sweat is slightly acidic. Saunas also increase the mean base excess by 20.3%